Antibody-Drug Conjugates: The 21st Century Magic Bullets for by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro PDF

By Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro

This authoritative quantity offers a holistic photo of antibody-drug conjugates (ADCs). Fourteen accomplished chapters are divided into six sections together with an creation to ADCs, the ADC build, improvement matters, panorama, IP and pharmacoeconomics, case experiences, and the way forward for the sector. The booklet examines every thing from the choice of the antibody, the drug, and the linker to a dialogue of developmental concerns resembling formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory demanding situations. It additionally explores pharmacoecomonics and highbrow homes, together with lately issued patents and the associated fee research of drug treatment. Case reviews are provided for the 3 ADCs that experience obtained FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), in addition to an ADC in late-stage scientific trials, glembatumumab vedotin (CDX-011). eventually, the amount offers a point of view by means of the editors at the destiny instructions of ADC improvement and scientific functions. Antibody-Drug Conjugates is a pragmatic and systematic source for scientists, professors, and scholars drawn to increasing their wisdom of state-of-the-art study during this intriguing field.

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Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series) by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro

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